Functional connectivity networks are disrupted in left temporal lobe epilepsy. (Article, 2006) [WorldCat.org]
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Functional connectivity networks are disrupted in left temporal lobe epilepsy.
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Functional connectivity networks are disrupted in left temporal lobe epilepsy.

Author: AB Waites Affiliation: Brain Research Institute, Austin Health, Heidelberg West, Victoria, Australia.; RS Briellmann; MM Saling; DF Abbott; GD Jackson
Edition/Format: Article Article : English
Publication:Annals of neurology, 2006 Feb; 59(2): 335-43
Other Databases: WorldCatWorldCat
Summary:
OBJECTIVE: Functional connectivity maps the distributed network of brain regions fluctuating synchronously during a continuous brain state. This study sought to investigate whether patients with left temporal lobe epilepsy (TLE) differ from controls in their resting-state functional connectivity between typical language regions. METHODS: We studied 17 patients with left TLE, together with eight healthy controls,  Read more...
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Details

Document Type: Article
All Authors / Contributors: AB Waites Affiliation: Brain Research Institute, Austin Health, Heidelberg West, Victoria, Australia.; RS Briellmann; MM Saling; DF Abbott; GD Jackson
ISSN:0364-5134
Language Note: English
Unique Identifier: 107906622
Awards:

Abstract:

OBJECTIVE: Functional connectivity maps the distributed network of brain regions fluctuating synchronously during a continuous brain state. This study sought to investigate whether patients with left temporal lobe epilepsy (TLE) differ from controls in their resting-state functional connectivity between typical language regions. METHODS: We studied 17 patients with left TLE, together with eight healthy controls, using seeded functional connectivity. Seed regions were defined using the regions of maximal activation and deactivation during a language functional magnetic resonance imaging (fMRI) task in a separate cohort of 30 controls. RESULTS: Language fMRI produced the expected activation pattern, which was not different between patients and controls. However, functional connectivity between language areas during rest was markedly different; whereas controls showed connectivity between each of the seed areas and the majority of the language areas, patients showed connectivity only with a few areas, particularly the seed area itself. This difference was significant in the direct comparison of patients and control connectivity maps. INTERPRETATION: We suggest that this reduced connectivity in left temporal lobe epilepsy may reflect a disturbance of the language network during resting state in patients and may be related to subtle language difficulties in this patient population.

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