Immunomodulatory potential of nanocurcumin-based formulation (Article, 2017) [WorldCat.org]
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Immunomodulatory potential of nanocurcumin-based formulation
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Immunomodulatory potential of nanocurcumin-based formulation

Author: Mahendra Kumar Trivedi Affiliation: Trivedi Global, Inc., Henderson, USA; Sambhu Charan Mondal Affiliation: Trivedi Science Research Laboratory Pvt. Ltd., Bhopal, Madhya Pradesh, India; Mayank Gangwar Affiliation: Trivedi Science Research Laboratory Pvt. Ltd., Bhopal, Madhya Pradesh, India; Snehasis Jana Affiliation: Trivedi Science Research Laboratory Pvt. Ltd., Bhopal, Madhya Pradesh, India, +91-755-2985921
Edition/Format: Article Article : English
Publication:Inflammopharmacology : Experimental and Therapeutic Studies, v25 n6 (201712): 609-619
Summary:
Vitamins, minerals, and nanocurcumin play a substantial role in various nutraceutical/pharmaceutical formulations that are widely used in therapeutics, cosmetics, and dietary supplements. The current study aimed to investigate the comparative in vitro immunomodulatory effect of a novel nanocurcumin-based formulation with curcumin in LPS-induced cytokine expression, NK cells’ activity, and phagocytosis. The  Read more...
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Document Type: Article
All Authors / Contributors: Mahendra Kumar Trivedi Affiliation: Trivedi Global, Inc., Henderson, USA; Sambhu Charan Mondal Affiliation: Trivedi Science Research Laboratory Pvt. Ltd., Bhopal, Madhya Pradesh, India; Mayank Gangwar Affiliation: Trivedi Science Research Laboratory Pvt. Ltd., Bhopal, Madhya Pradesh, India; Snehasis Jana Affiliation: Trivedi Science Research Laboratory Pvt. Ltd., Bhopal, Madhya Pradesh, India, +91-755-2985921
ISSN:0925-4692
Language Note: English
Unique Identifier: 7176061300
Notes: Acknowledgements: The authors are grateful to the support of Trivedi Science, Trivedi Global, Inc., and Trivedi Master Wellness throughout the work. Authors also thankful to Dabur Research Foundation (DRF) for conducting the experiment.
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Abstract:

Vitamins, minerals, and nanocurcumin play a substantial role in various nutraceutical/pharmaceutical formulations that are widely used in therapeutics, cosmetics, and dietary supplements. The current study aimed to investigate the comparative in vitro immunomodulatory effect of a novel nanocurcumin-based formulation with curcumin in LPS-induced cytokine expression, NK cells’ activity, and phagocytosis. The proinflammatory cytokines (TNF-α, IL-1β, and MIP-1α) and NK cells’ activity were measured in cell supernatants using ELISA assay; however, phagocytosis activity was performed using colorimetric analysis. The chemical characterization of novel nanocurcumin-based formulation using LC-MS (R t 19.02 min) and mass spectra analysis (m/z 369.04) confirmed the presence of the curcumin in highest peak concentration. MTT assay in three tested cell-lines showed that the formulation was found non-toxic at all the tested concentrations. The expression of TNF-α, IL-1β, and MIP-1α in splenocytes was significantly (p ≤ 0.001) inhibited. Besides, the NK cells’ activity and phagocytosis (macrophage) were increased significantly (p ≤ 0.001). Overall, the promising results of this study indicated the significant immunomodulatory effect of nanocurcumin-based formulation compared to the curcumin, which could be used against various inflammatory disorders such as allergy, asthma, autoimmune diseases, coeliac disease, inflammatory bowel disease, etc.

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